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Complete trials on adults first: Govt panel says no to Covovax trial by SII


New Delhi: In a big setback to COVID vaccine maker Serum Institute of India (SII), an expert panel of the country’s central drug authority has recommended against granting permission to SII to conduct the phase 2/3 trial of COVID-19 vaccine Covovax on children aged two to 17 years.

The SII has applied to the Drugs Controller General of India (DCGI) on Monday seeking permission for conducting a trial of Covovax on 920 children, 460 each in the 12-17 and 2-11 age groups, at 10 sites.

“The Subject Expert Committee (SEC) on COVID-19 of the Central Drugs Standard Control Organisation (CDSCO), which deliberated on the application, noted that the vaccine has not been approved in any country,” a source said.

“It also recommended that the Pune-based company should submit the safety and immunogenicity data (of Covovax) from the ongoing clinical trial in adults for considering the conduct of a clinical trial in children,” the source said.

 

 

The recommendations are learnt to have been approved by the DCGI. In August 2020, US-based vaccine maker Novavax Inc. 

Had announced a licence agreement with the SII for the development and commercialisation of NVX-CoV2373, its COVID-19 vaccine candidate, in low and middle-income countries and India.

The clinical trials of Covovax began in India in March and the SII hopes to launch it by September for adults. In January, the SII had rolled out the Covishield vaccine in the country. It had entered into a collaboration with the University of Oxford and AstraZeneca to manufacture the vaccine. 

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